Debunking the Frailty-sarcopenIa-ADT Axis in mEtastatic Prostate canceR With multiComponent Exercise: The FIERCE Trial
The purpose of this study is to determine whether a 16-week supervised, clinic-based circuit training intervention utilizing resistance and functional exercises and self-directed aerobic exercise will improve frailty and sarcopenic status and disease progression outcomes among pre-frail/frail metastatic prostate cancer patients receiving androgen deprivation therapy (ADT). The names of the study intervention involved in this study is: • Supervised circuit training (aerobic and resistance exercise regimen)
• Ability to understand and the willingness to sign informed consent prior to any study-related procedures.
• Diagnosed with metastatic prostate cancer.
• Aged ≥18 years; due to the rarity of the disease in those \<18 years, this age bracket will not be included.
• Have been receiving androgen deprivation (either with or without androgen receptor targeted treatment) for at least one month and expect to remain on their treatment for at least 4 months.
• Are pre-frail or frail as indicated by the FRAIL scale (a score of 1-2 = pre-frail; 3-5 = frail).
• Have physician's clearance to participate in exercise.
• Speak English.
• Participate in less than 2 structured resistance exercise sessions per week over the last 4 months.
• Participate in less than or equal to 60 minutes of moderate-to-vigorous aerobic exercise per week over the last month.
• Willing to travel to Dana-Farber Cancer Institute for necessary data collection and exercise sessions.